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10.11606/s1518-8787.2020054002631 http://scihub22266oqcxt.onion/10.11606/s1518-8787.2020054002631 C7319500!7319500 !32638884     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32638884 &cmd=llinks): Failed to open stream: HTTP request failed! 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Primum non nocere - Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19)? |pdf=|usr=}}{{32638884 }} gab.com Text Primum non nocere - Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19) JO: Rev Saude Publica http://www.kidney.de/pget.php?&tw=1&pmid=32638884 #FOAvip Chloroquine (CQ) and its analog hydroxychloroquine (HCQ) were recently included in several clinical trials as potential prophylactic and therapeutic options for SARS-COV-2 infection/covid-19. However, drug effectiveness in preventing, treating, or slowing the progression of the disease is still unknown. Despite some initial promising in vitro results, rigorous pre-clinical animal studies and randomized clinical trials have not been performed yet. On the other hand, while the potential effectiveness of CQ/HCQ is, at best, hypothetical, their side effects are factual and most worrisome, particularly when considering vulnerable groups of patients being treated with these drugs. in this comment, we briefly explain the possible mechanisms of action of CQ/HCQ for treating other diseases, possible actions against covid-19, and their potent side effects, in order to reinforce the necessity of evaluating the benefit-risk balance when widely prescribing these drugs for SARS-COV-2 infection/covid-19. We conclude by strongly recommending against their indiscriminate use. Twit Text FOAVip Primum non nocere - Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19) ????Rev Saude Publica http://www.kidney.de/pget.php?&tw=1&pmid=32638884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32638884 #FOAvip English Wikipedia <ref>{{Cite pmid|32638884 }}</ref> Primum non nocere - Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19)? #MMPMID32638884 Biguetti C ; Marrelli MT ; Brotto M Rev Saude Publica 2020[]; 54 (ä): 68 PMID32638884 show ga Chloroquine (CQ) and its analog hydroxychloroquine (HCQ) were recently included in several clinical trials as potential prophylactic and therapeutic options for SARS-COV-2 infection/covid-19. However, drug effectiveness in preventing, treating, or slowing the progression of the disease is still unknown. Despite some initial promising in vitro results, rigorous pre-clinical animal studies and randomized clinical trials have not been performed yet. On the other hand, while the potential effectiveness of CQ/HCQ is, at best, hypothetical, their side effects are factual and most worrisome, particularly when considering vulnerable groups of patients being treated with these drugs. in this comment, we briefly explain the possible mechanisms of action of CQ/HCQ for treating other diseases, possible actions against covid-19, and their potent side effects, in order to reinforce the necessity of evaluating the benefit-risk balance when widely prescribing these drugs for SARS-COV-2 infection/covid-19. We conclude by strongly recommending against their indiscriminate use. |*Betacoronavirus/drug effects [MESH] |Antimalarials/adverse effects/pharmacokinetics/*pharmacology [MESH] |COVID-19 [MESH] |COVID-19 Drug Treatment [MESH] |Chloroquine/adverse effects/pharmacokinetics/*pharmacology [MESH] |Contraindications, Drug [MESH] |Coronavirus Infections/*drug therapy [MESH] |Humans [MESH] |Hydroxychloroquine/adverse effects/pharmacokinetics/*pharmacology [MESH] |Pandemics [MESH] |Pneumonia, Viral/*drug therapy [MESH] |Risk Assessment [MESH]Primum non nocere - Are chloroquine and hydroxychloroquine safe prop(epmc).pdf DeepDyve Pubget Overpricing