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10.1186/s40246-020-00276-2 http://scihub22266oqcxt.onion/10.1186/s40246-020-00276-2 C7318728!7318728 !32591003     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32591003 &cmd=llinks): Failed to open stream: HTTP request failed! 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Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery |pdf=|usr=}}{{32591003 }} gab.com Text Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery JO: Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32591003 #FOAvip Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two instruments of basic and translational research, which both allow to acquire deep insight about the molecular bases of many diseases but also to develop pharmacological research.This review is focused to draw up the latest technique of gene editing applied on hiPSCs, exploiting some of the genetic manipulation directed to the discovery of innovative therapeutic strategies. There are many expediencies provided by the use of hiPSCs, which can represent a disease model clinically relevant and predictive, with a great potential if associated to CRISPR/Cas9 technology, a gene editing tool powered by ease and precision never seen before.Here, we describe the possible applications of CRISPR/Cas9 to hiPSCs: from drug development to drug screening and from gene therapy to the induction of the immunological response to specific virus infection, such as HIV and SARS-Cov-2. Twit Text FOAVip Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery ????Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32591003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32591003 #FOAvip English Wikipedia <ref>{{Cite pmid|32591003 }}</ref> Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery #MMPMID32591003 De Masi C ; Spitalieri P ; Murdocca M ; Novelli G ; Sangiuolo F Hum Genomics 2020[Jun]; 14 (1 ): 25 PMID32591003 show ga Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two instruments of basic and translational research, which both allow to acquire deep insight about the molecular bases of many diseases but also to develop pharmacological research.This review is focused to draw up the latest technique of gene editing applied on hiPSCs, exploiting some of the genetic manipulation directed to the discovery of innovative therapeutic strategies. There are many expediencies provided by the use of hiPSCs, which can represent a disease model clinically relevant and predictive, with a great potential if associated to CRISPR/Cas9 technology, a gene editing tool powered by ease and precision never seen before.Here, we describe the possible applications of CRISPR/Cas9 to hiPSCs: from drug development to drug screening and from gene therapy to the induction of the immunological response to specific virus infection, such as HIV and SARS-Cov-2. |*CRISPR-Cas Systems [MESH] |*Drug Discovery [MESH] |*Gene Editing [MESH] |*Genetic Therapy [MESH] |Animals [MESH] |Cellular Reprogramming [MESH] |Humans [MESH] |Induced Pluripotent Stem Cells/*cytology/metabolism/transplantation [MESH]Application of CRISPR/Cas9 to human-induced pluripotent stem cells: fr(epmc).pdf DeepDyve Pubget Overpricing