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2020 ; 15
(6
): e0235107
Nephropedia Template TP
gab.com Text
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English Wikipedia
Sociodemographic, clinical and laboratory factors on admission associated with
COVID-19 mortality in hospitalized patients: A retrospective observational study
#MMPMID32584868
Rivera-Izquierdo M
; Del Carmen Valero-Ubierna M
; R-delAmo JL
; Fernández-García MÁ
; Martínez-Diz S
; Tahery-Mahmoud A
; Rodríguez-Camacho M
; Gámiz-Molina AB
; Barba-Gyengo N
; Gámez-Baeza P
; Cabrero-Rodríguez C
; Guirado-Ruiz PA
; Martín-Romero DT
; Láinez-Ramos-Bossini AJ
; Sánchez-Pérez MR
; Mancera-Romero J
; García-Martín M
; Martín-delosReyes LM
; Martínez-Ruiz V
; Lardelli-Claret P
; Jiménez-Mejías E
PLoS One
2020[]; 15
(6
): e0235107
PMID32584868
show ga
BACKGROUND: To identify and quantify associations between baseline
characteristics on hospital admission and mortality in patients with COVID-19 at
a tertiary hospital in Spain. METHODS AND FINDINGS: This retrospective case
series included 238 patients hospitalized for COVID-19 at Hospital Universitario
Clínico San Cecilio (Granada, Spain) who were discharged or who died. Electronic
medical records were reviewed to obtain information on sex, age, personal
antecedents, clinical features, findings on physical examination, and laboratory
results for each patient. Associations between mortality and baseline
characteristics were estimated as hazard ratios (HR) calculated with Cox
regression models. Series mortality was 25.6%. Among patients with dependence for
basic activities of daily living, 78.7% died, and among patients residing in
retirement homes, 80.8% died. The variables most clearly associated with a
greater hazard of death were age (3% HR increase per 1-year increase in age;
95%CI 1-6), diabetes mellitus (HR 2.42, 95%CI 1.43-4.09), SatO2/FiO2 ratio (43%
HR reduction per 1-point increase; 95%CI 23-57), SOFA score (19% HR increase per
1-point increase, 95%CI 5-34) and CURB-65 score (76% HR increase per 1-point
increase, 95%CI 23-143). CONCLUSIONS: The patients residing in retirement homes
showed great vulnerability. The main baseline factors that were independently
associated with mortality in patients hospitalized for COVID-19 were older age,
diabetes mellitus, low SatO2/FiO2 ratio, and high SOFA and CURB-65 scores.