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2020 ; 139
(ä): 110046
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Forecasting COVID-19 pandemic: A data-driven analysis
#MMPMID32834601
Nabi KN
Chaos Solitons Fractals
2020[Oct]; 139
(ä): 110046
PMID32834601
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In this paper, a new Susceptible-Exposed-Symptomatic Infectious-Asymptomatic
Infectious-Quarantined-Hospitalized-Recovered-Dead (SEI(D)I(U)QHRD) deterministic
compartmental model has been proposed and calibrated for interpreting the
transmission dynamics of the novel coronavirus disease (COVID-19). The purpose of
this study is to give tentative predictions of the epidemic peak for Russia,
Brazil, India and Bangladesh which could become the next COVID-19 hotspots in no
time by using a newly developed algorithm based on well-known
Trust-region-reflective (TRR) algorithm, which is one of the robust real-time
optimization techniques. Based on the publicly available epidemiological data
from late January until 10 May, it has been estimated that the number of daily
new symptomatic infectious cases for the above mentioned countries could reach
the peak around the middle of June with the peak size of ???15, 774 (95% CI,
12,814-16,734) symptomatic infectious cases in Russia, ???26, 449 (95% CI,
25,489-31,409) cases in Brazil, ???9, 504 (95% CI, 8,378-13,630) cases in India
and ???2, 209 (95% CI, 2,078-2,840) cases in Bangladesh if current epidemic
trends hold. As of May 11, 2020, incorporating the infectiousness capability of
asymptomatic carriers, our analysis estimates the value of the basic reproductive
number (R (0)) was found to be ???4.234 (95% CI, 3.764-4.7) in Russia, ???5.347
(95% CI, 4.737-5.95) in Brazil, ???5.218 (95% CI, 4.56-5.81) in India, ???4.649
(95% CI, 4.17-5.12) in the United Kingdom and ???3.53 (95% CI, 3.12-3.94) in
Bangladesh. Moreover, Latin hypercube sampling-partial rank correlation
coefficient (LHS-PRCC) which is a global sensitivity analysis (GSA) method has
been applied to quantify the uncertainty of our model mechanisms, which
elucidates that for Russia, the recovery rate of undetected asymptomatic
carriers, the rate of getting home-quarantined or self-quarantined and the
transition rate from quarantined class to susceptible class are the most
influential parameters, whereas the rate of getting home-quarantined or
self-quarantined and the inverse of the COVID-19 incubation period are highly
sensitive parameters in Brazil, India, Bangladesh and the United Kingdom which
could significantly affect the transmission dynamics of the novel coronavirus
disease (COVID-19). Our analysis also suggests that relaxing social distancing
restrictions too quickly could exacerbate the epidemic outbreak in the
above-mentioned countries.