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2020 ; 2020
(ä): 6925296
Nephropedia Template TP
gab.com Text
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English Wikipedia
Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a
Concerted Effort by the Global Community
#MMPMID32607499
Luo Z
; Ang MJY
; Chan SY
; Yi Z
; Goh YY
; Yan S
; Tao J
; Liu K
; Li X
; Zhang H
; Huang W
; Liu X
Research (Wash D C)
2020[]; 2020
(ä): 6925296
PMID32607499
show ga
The World Health Organization (WHO) has declared the outbreak of 2019 novel
coronavirus, known as 2019-nCoV, a pandemic, as the coronavirus has now infected
over 2.6 million people globally and caused more than 185,000 fatalities as of
April 23, 2020. Coronavirus disease 2019 (COVID-19) causes a respiratory illness
with symptoms such as dry cough, fever, sudden loss of smell, and, in more severe
cases, difficulty breathing. To date, there is no specific vaccine or treatment
proven effective against this viral disease. Early and accurate diagnosis of
COVID-19 is thus critical to curbing its spread and improving health outcomes.
Reverse transcription-polymerase chain reaction (RT-PCR) is commonly used to
detect the presence of COVID-19. Other techniques, such as recombinase polymerase
amplification (RPA), loop-mediated isothermal amplification (LAMP), clustered
regularly interspaced short palindromic repeats (CRISPR), and microfluidics, have
allowed better disease diagnosis. Here, as part of the effort to expand screening
capacity, we review advances and challenges in the rapid detection of COVID-19 by
targeting nucleic acids, antigens, or antibodies. We also summarize potential
treatments and vaccines against COVID-19 and discuss ongoing clinical trials of
interventions to reduce viral progression.