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A brand-new cardiorenal syndrome in the COVID-19 setting #MMPMID32695320
Apetrii M; Enache S; Siriopol D; Burlacu A; Kanbay A; Kanbay M; Scripcariu D; Covic A
Clin Kidney J 2020[Jun]; 13 (3): 291-6 PMID32695320show ga
Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient?s lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.