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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Herb+Med 2020 ; 23 (ä): 100382 Nephropedia Template TP
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Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19 #MMPMID32834942
Rahman MT
J Herb Med 2020[Oct]; 23 (ä): 100382 PMID32834942show ga
The SARS-CoV binds its spike (S) proteins to host angiotensin-converting enzyme 2 (ACE2). Following entry, the viral RNA is released in the cytoplasm - a potential site of thymoquinone to stop the release. ORF1a and ORF1ab are translated to RdRP which eventually synthesizes mediate both replication and transcription. The Zn2+ can stop viral replication by inactivating (?|) RdRP. Another bioactive component of black seed i.e., nigellimine might have dual actions working as ionophore (?) to enhance Zn entry into the infected cells as well as to inhibit (?|) the uncoating of the virus inside the infected cells. However, if allowed to continue, replication, full-length (?) RNA copies of the genome are produced and used as templates for full-length (+) RNA genomes. During transcription, sub-genomic RNAs are produced through discontinuous transcription which are eventually translated to synthesize viral proteins. Generally, viral nucleocapsids are assembled from genomic RNA and N protein in the cytoplasm, followed by budding into the lumen of the endoplasmic reticulum?Golgi intermediate compartment. Virions are then released from the infected cell through exocytosis. (?, activation or stimulation; ?|, inhibition) (modified from (Rahman and Idid, 2020).