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10.1016/j.cell.2020.06.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.025 C7311918!7311918 !32645326     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32645326 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2020 ; 182 (4 ): 828-842.e16 Nephropedia Template TP {{tp|p=32645326 |t=2020. Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies |pdf=|usr=}}{{32645326 }} gab.com Text Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32645326 #FOAvip Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their focus on RBD epitopes, recognition of alpha- and beta-coronaviruses, and contributions of avidity to increased binding/neutralization of IgGs over Fabs. Using electron microscopy, we examined specificities of polyclonal plasma Fabs, revealing recognition of both S1(A) and RBD epitopes on SARS-CoV-2 spike. Moreover, a 3.4 Å cryo-electron microscopy (cryo-EM) structure of a neutralizing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding. Modeling based on these structures suggested different potentials for inter-spike crosslinking by IgGs on viruses, and characterized IgGs would not be affected by identified SARS-CoV-2 spike mutations. Overall, our studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3-53/VH3-66 and similarity to a SARS-CoV VH3-30 antibody, providing criteria for evaluating vaccine-elicited antibodies. Twit Text FOAVip Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32645326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32645326 #FOAvip English Wikipedia <ref>{{Cite pmid|32645326 }}</ref> Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies #MMPMID32645326 Barnes CO ; West AP Jr ; Huey-Tubman KE ; Hoffmann MAG ; Sharaf NG ; Hoffman PR ; Koranda N ; Gristick HB ; Gaebler C ; Muecksch F ; Lorenzi JCC ; Finkin S ; Hägglöf T ; Hurley A ; Millard KG ; Weisblum Y ; Schmidt F ; Hatziioannou T ; Bieniasz PD ; Caskey M ; Robbiani DF ; Nussenzweig MC ; Bjorkman PJ Cell 2020[Aug]; 182 (4 ): 828-842.e16 PMID32645326 show ga Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their focus on RBD epitopes, recognition of alpha- and beta-coronaviruses, and contributions of avidity to increased binding/neutralization of IgGs over Fabs. Using electron microscopy, we examined specificities of polyclonal plasma Fabs, revealing recognition of both S1(A) and RBD epitopes on SARS-CoV-2 spike. Moreover, a 3.4 Å cryo-electron microscopy (cryo-EM) structure of a neutralizing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding. Modeling based on these structures suggested different potentials for inter-spike crosslinking by IgGs on viruses, and characterized IgGs would not be affected by identified SARS-CoV-2 spike mutations. Overall, our studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3-53/VH3-66 and similarity to a SARS-CoV VH3-30 antibody, providing criteria for evaluating vaccine-elicited antibodies. |Antibodies, Neutralizing/blood/*chemistry/isolation & purification [MESH] |Antibodies, Viral/immunology/isolation & purification [MESH] |Betacoronavirus/*chemistry/immunology [MESH] |COVID-19 [MESH] |COVID-19 Serotherapy [MESH] |Coronavirus Infections/blood/*immunology/therapy [MESH] |Cross Reactions [MESH] |Cryoelectron Microscopy [MESH] |Epitope Mapping [MESH] |Epitopes [MESH] |Humans [MESH] |Immunization, Passive [MESH] |Immunoglobulin Fab Fragments/blood/*chemistry/isolation & purification/ultrastructure [MESH] |Immunoglobulin G/blood/*chemistry/isolation & purification/ultrastructure [MESH] |Middle East Respiratory Syndrome Coronavirus/chemistry/immunology [MESH] |Models, Molecular [MESH] |Pandemics [MESH] |Pneumonia, Viral/blood/*immunology [MESH] |SARS-CoV-2 [MESH] |Severe acute respiratory syndrome-related coronavirus/chemistry/immunology [MESH]Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common(epmc).pdf DeepDyve Pubget Overpricing