Cardiac Injury and COVID-19: A Systematic Review and Meta-analysis
#MMPMID32838255
Zou F
; Qian Z
; Wang Y
; Zhao Y
; Bai J
CJC Open
2020[Sep]; 2
(5
): 386-394
PMID32838255
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BACKGROUND: During the current COVID-19 pandemic, a link between acute cardiac
injury and COVID-19 infection has been observed. There is currently no consensus
on the incidence of cardiac injury, its relationship to prognosis, or its
possible cause. In this article we provide a comprehensive review and
meta-analysis of the incidence, comorbidities, outcomes, and possible mechanisms
of acute cardiac injury in COVID-19 patients. METHODS: We searched PubMed and
Embase for studies that evaluated cardiac injury in hospitalized COVID-19
patients. Data on demographic information, comorbidities, and relevant laboratory
values were extracted and a meta-analysis was performed. RESULTS: Sixteen studies
from China, Italy, and the United States with 2224 patients were included in this
meta-analysis. The incidence of cardiac injury was 24.4% (542/2224 patients) in
hospitalized COVID-19 patients. The all-cause mortality in patients with cardiac
injury was 72.6% (odds ratio, 17.32; 95% confidence interval, 9.21-32.57)
compared with those without cardiac injury (14.5%). In subgroup analyses, factors
associated with increased risk of developing cardiac injury were older age and
history of hypertension, and chronic obstructive respiratory disease.
CONCLUSIONS: Cardiac injury is common in hospitalized COVID-19 patients and is
significantly associated with mortality. Patients who were older with
hypertension and chronic obstructive respiratory disease were prone to develop
cardiac injury. Early screening, triage, and cardiac monitoring are recommended
for these patients.
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