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2020 ; 22
(9
): 500-503
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Predictive factors of mortality in patients treated with tocilizumab for acute
respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)
#MMPMID32574789
Lohse A
; Klopfenstein T
; Balblanc JC
; Royer PY
; Bossert M
; Gendrin V
; Charpentier A
; Bozgan AM
; Badie J
; Bourgoin C
; Contreras R
; Mazurier I
; Conrozier T
; Zayet S
Microbes Infect
2020[Oct]; 22
(9
): 500-503
PMID32574789
show ga
COVID-19 patients (n = 34) suffering from ARDS were treated with tocilizumab
(TCZ). Outcome was classified in two groups: "Death" and "Recovery". Predictive
factors of mortality were studied. Mean age was 75.3, mean oxygen (O(2))
requirements 10.4 l/min. At baseline, all patients had multiple biological
abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and
liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died
(29.5%). Deceased subjects differed from patients in whom treatment was effective
with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p = 0.037), lower
platelet number (156 vs 314 G/l; p = 0.0001), lower fibrinogen serum level (0.6
vs 1.0 G/l; p = 0.03), higher aspartate-amino-transferase (108 vs 57 UI/l;
p = 0.05) and greater O(2) requirements (11 vs 8 l/min; p = 0.003).
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Anti-Bacterial Agents/therapeutic use
[MESH]
|Antibodies, Monoclonal, Humanized/*therapeutic use
[MESH]