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Known drugs and small molecules in the battle for COVID-19 treatment
#MMPMID32837982
Panoutsopoulos AA
Genes Dis
2020[Dec]; 7
(4
): 528-534
PMID32837982
show ga
COVID-19 has been declared a pandemic by the World Health Organization on March
11th and since then more than 3 million cases and a quarter million deaths have
occurred due to it. The urge to find a resultful treatment or cure is now
pressing more than any other time since the outbreak of the pandemic. Researchers
all over the world from different fields of expertise are trying to find the most
suitable drugs, that are already known to treat other diseases, and could tackle
the process of SARS-CoV2 through which it invades and replicates in human cells.
Here, we discuss five of the most promising drugs that can potentially play a
major role in the treatment of COVID-19. While nicotine and ivermectin may be
blocking transport abilities of the virus or its components, famotidine,
remdesivir and chloroquine in combination with zinc ions can deactivate important
enzymes needed for the replication of the virus. While clinical trials for some
of these drugs have already started, it is common knowledge that lack of
organization between countries, institutes and hospitals might slow down the
whole process for an official treatment based in wide, randomized, placebo
controlled trials.
free
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