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Systemic steroids and risk of fecal-oral shedding and increased transmission of
SARS-CoV-2 in pemphigus cases
#MMPMID33341209
Pawar M
; Singh M
Clin Dermatol
2020[Nov]; 38
(6
): 750-756
PMID33341209
show ga
Pemphigus and its variants, viz., vulgaris, foliaceous, vegetans, Ig A pemphigus,
paraneoplastic pemphigus and Senear-Usher syndrome are rare autoimmune blistering
diseases of the skin and/or mucous membranes. The autoantibodies involved in the
pathogenesis of pemphigus against desmoglein result in the breach of the skin and
mucosal barrier, which acts as the first line of defence against pathogens. In
this paper we underscore the importance of the integumentary system as a shield
against the acquisition as well as transmission of SARS-CoV-2 virion. We have
also made an attempt to delineate the various treatment modalities available and
the viral-drug dynamics involved in choosing the optimum therapeutic modality.
|*Virus Shedding/drug effects
[MESH]
|Administration, Oral
[MESH]
|Adrenal Cortex Hormones/adverse effects/*therapeutic use
[MESH]
free
free
free
