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10.1016/j.medidd.2020.100054

http://scihub22266oqcxt.onion/10.1016/j.medidd.2020.100054
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C7303026!7303026!C7303026
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suck abstract from ncbi

pmidC7303026      Med+Drug+Discov 2020 ; 7 (ä): 100054
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  • ET-traps as a potential treatment for COVID-19 #MMPMIDC7303026
  • Jain A; Mehrotra V
  • Med Drug Discov 2020[Sep]; 7 (ä): 100054 PMIDC7303026show ga
  • The ET-traps are Fc-fusion proteins that have shown a therapeutic potential in the diabetes disease space. Previous studies have also discussed the potential use of ET-traps for other diseases, including HIV / AIDS. These diseases are all associated with pathologically elevated endothelin ?1 (ET-1) levels. This paper discusses the potential use of ET-traps for the COVID-19 pandemic, which previous studies have shown involves high cytokine levels. Research has also shown that ET-1 is a stimulus for the induction of these pro-inflammatory cytokines. Hence, the ET-traps would likely be effective in patients suffering from COVID-19. If successful at the preclinical and clinical testing, the ET- traps would provide a much-awaited therapy.
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