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2020 ; 20
(1
): 248
Nephropedia Template TP
gab.com Text
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English Wikipedia
Acute encephalopathy with elevated CSF inflammatory markers as the initial
presentation of COVID-19
#MMPMID32552792
Farhadian S
; Glick LR
; Vogels CBF
; Thomas J
; Chiarella J
; Casanovas-Massana A
; Zhou J
; Odio C
; Vijayakumar P
; Geng B
; Fournier J
; Bermejo S
; Fauver JR
; Alpert T
; Wyllie AL
; Turcotte C
; Steinle M
; Paczkowski P
; Dela Cruz C
; Wilen C
; Ko AI
; MacKay S
; Grubaugh ND
; Spudich S
; Barakat LA
BMC Neurol
2020[Jun]; 20
(1
): 248
PMID32552792
show ga
BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus
SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic
complications can be the presenting manifestation in a subset of infected
patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman
who presented with altered mental status after witnessed seizure-like activity at
home. She was found to have SARS-CoV-2 infection and associated
neuroinflammation. In this case, we undertake the first detailed analysis of
cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique
pattern of inflammation in CSF, but no evidence of viral neuroinvasion.
CONCLUSION: Our findings suggest that neurologic symptoms such as encephalopathy
and seizures may be the initial presentation of COVID-19. Central nervous system
inflammation may associate with neurologic manifestations of disease.