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10.1186/s12883-020-01812-2

http://scihub22266oqcxt.onion/10.1186/s12883-020-01812-2
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suck abstract from ncbi


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pmid32552792
      BMC+Neurol 2020 ; 20 (1 ): 248
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  • Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 #MMPMID32552792
  • Farhadian S ; Glick LR ; Vogels CBF ; Thomas J ; Chiarella J ; Casanovas-Massana A ; Zhou J ; Odio C ; Vijayakumar P ; Geng B ; Fournier J ; Bermejo S ; Fauver JR ; Alpert T ; Wyllie AL ; Turcotte C ; Steinle M ; Paczkowski P ; Dela Cruz C ; Wilen C ; Ko AI ; MacKay S ; Grubaugh ND ; Spudich S ; Barakat LA
  • BMC Neurol 2020[Jun]; 20 (1 ): 248 PMID32552792 show ga
  • BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. CONCLUSION: Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
  • |*Betacoronavirus [MESH]
  • |*Coronavirus Infections [MESH]
  • |*Encephalitis, Viral [MESH]
  • |*Pandemics [MESH]
  • |*Pneumonia, Viral [MESH]
  • |Acute Disease [MESH]
  • |Aged [MESH]
  • |Biomarkers/cerebrospinal fluid [MESH]
  • |COVID-19 [MESH]
  • |Cytokines/*cerebrospinal fluid [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |SARS-CoV-2 [MESH]


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