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10.1038/s41467-020-16876-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-16876-4 C7300015!7300015 !32555182     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32555182 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2020 ; 11 (1 ): 3070 Nephropedia Template TP {{tp|p=32555182 |t=2020. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution |pdf=|usr=}}{{32555182 }} gab.com Text Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32555182 #FOAvip Porcine coronavirus SADS-CoV has been identified from suckling piglets with severe diarrhea in southern China in 2017. The SADS-CoV genome shares ~95% identity to that of bat ?-coronavirus HKU2, suggesting that SADS-CoV may have emerged from a natural reservoir in bats. Here we report the cryo-EM structures of HKU2 and SADS-CoV spike (S) glycoprotein trimers at 2.38?Å and 2.83?Å resolution, respectively. We systematically compare the domains of HKU2 spike with those of ?-, ?-, ?-, and ?-coronavirus spikes, showing that the S1 subunit N- and C-terminal domains of HKU2/SADS-CoV are ancestral domains in the evolution of coronavirus spike proteins. The connecting region after the fusion peptide in the S2 subunit of HKU2/SADS-CoV adopts a unique conformation. These results structurally demonstrate a close evolutionary relationship between HKU2/SADS-CoV and ?-coronavirus spikes and provide insights into the evolution and cross-species transmission of coronaviruses. Twit Text FOAVip Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32555182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32555182 #FOAvip English Wikipedia <ref>{{Cite pmid|32555182 }}</ref> Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution #MMPMID32555182 Yu J ; Qiao S ; Guo R ; Wang X Nat Commun 2020[Jun]; 11 (1 ): 3070 PMID32555182 show ga Porcine coronavirus SADS-CoV has been identified from suckling piglets with severe diarrhea in southern China in 2017. The SADS-CoV genome shares ~95% identity to that of bat ?-coronavirus HKU2, suggesting that SADS-CoV may have emerged from a natural reservoir in bats. Here we report the cryo-EM structures of HKU2 and SADS-CoV spike (S) glycoprotein trimers at 2.38?Å and 2.83?Å resolution, respectively. We systematically compare the domains of HKU2 spike with those of ?-, ?-, ?-, and ?-coronavirus spikes, showing that the S1 subunit N- and C-terminal domains of HKU2/SADS-CoV are ancestral domains in the evolution of coronavirus spike proteins. The connecting region after the fusion peptide in the S2 subunit of HKU2/SADS-CoV adopts a unique conformation. These results structurally demonstrate a close evolutionary relationship between HKU2/SADS-CoV and ?-coronavirus spikes and provide insights into the evolution and cross-species transmission of coronaviruses. |Alphacoronavirus/*chemistry [MESH] |Animals [MESH] |Cell Line [MESH] |Chiroptera [MESH] |Coronavirus Infections [MESH] |Cryoelectron Microscopy [MESH] |Evolution, Molecular [MESH] |Glycoproteins/ultrastructure [MESH] |Humans [MESH] |Models, Molecular [MESH] |Protein Domains [MESH] |Spike Glycoprotein, Coronavirus/*ultrastructure [MESH]Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide in(epmc).pdf DeepDyve Pubget Overpricing