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2020 ; 17
(10
): 559-61
Nephropedia Template TP
gab.com Text
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English Wikipedia
Anakinra, una alternativa potencial en el tratamiento de la infección
respiratoria grave por SARS-CoV-2 refractaria a tocilizumab
#MMPMID32571730
Figuero-Pérez L
; Olivares-Hernández A
; Escala-Cornejo RA
; Terán-Brage E
; López-Gutiérrez Á
; Cruz-Hernández JJ
Reumatol Clin (Engl Ed)
2020[Jun]; 17
(10
): 559-61
PMID32571730
show ga
SARS-CoV-2 is a new RNA virus which causes coronavirus disease 2019 (COVID-19),
declared a pandemic by the World Health Organization (WHO). It triggers an
atypical pneumonia that can progress to multiorgan failure. COVID-19 can cause
dysregulation of the immune system, triggering an inflammatory response, and
simulate haemophagocytic lymphohistiocytosis. Several studies have proposed that
anti-IL-6 receptor antibodies, such as tocilizumab, play an important role in the
treatment of severe acute respiratory infection associated with SARS-CoV-2.
However, the role of anti-IL-1 receptor antibodies, such as anakinra, in the
treatment of COVID-19 has not been established. We present a case report of a
51-year-old man diagnosed with severe respiratory infection associated with
SARS-CoV-2 that was refractory to antiviral and anti-IL-6 treatment, with a
favourable clinical outcome and analytical improvement after treatment with
anti-IL-1 (anakinra).