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10.1021/acs.oprd.0c00233

http://scihub22266oqcxt.onion/10.1021/acs.oprd.0c00233
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C7294877!7294877!37556267
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suck abstract from ncbi


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pmid37556267      Org+Process+Res+Dev 2020 ; 24 (6): 940-76
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  • Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply #MMPMID37556267
  • De Savi C; Hughes DL; Kvaerno L
  • Org Process Res Dev 2020[Jun]; 24 (6): 940-76 PMID37556267show ga
  • The outbreak of the COVID-19 pandemic has spurred an intense global effort to repurpose existing approved drugs for its treatment. In this review, we highlight the development of seven small-molecule drugs that are currently being assessed in clinical trials for the treatment of COVID-19. Three sections are presented for each drug: (1) history, mechanism of action, and status of clinical trials; (2) scalable synthetic routes and final forms; and (3) outlook for supply should clinical trials show treatment efficacy. A brief overview of diagnostic testing and vaccine development is also presented.
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