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2019 novel-coronavirus: Cardiovascular insights about risk factors, myocardial
injury, therapy and clinical implications
#MMPMID32837764
Cappannoli L
; Scacciavillani R
; Iannaccone G
; Anastasia G
; Di Giusto F
; Loria V
; Aspromonte N
Chronic Dis Transl Med
2020[Dec]; 6
(4
): 246-250
PMID32837764
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From December 31st, 2019, a novel highly pathogenic coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, reaching
at present the dimension of a pandemic. In addition to damaging the lungs,
SARS-CoV-2 may also damage the heart and this is corroborated by the evidence
that cardiovascular comorbidities are associated with a higher mortality and poor
clinical outcomes in patient infected by the virus. During the infection
myocardial injury, myocarditis and arrhythmias have also been reported, but the
pathophysiological mechanisms of these complications are yet to be understood.
Great attention is also being posed on the potential beneficial/harmful role of
angiotensin converting enzyme (ACE) inhibitors, as far as the virus binds to ACE2
to infect cells, but evidences lack. Furthermore, SARS-CoV-2 can also affect the
aspect of acute coronary syndromes, not only because these two distinct
pathological entities share pathogenic aspects (such as the systemic inflammatory
state and cytokine release), but also and above all for the consequences that the
need to contain the infection has on the management of cardiological urgencies.
The aim of this review was therefore to summarize the relationship between the
virus and the cardiovascular system.
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