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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pediatr+Cardiol
2020 ; 41
(7
): 1391-1401
Nephropedia Template TP
gab.com Text
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English Wikipedia
Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with
SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a
UK Tertiary Paediatric Hospital
#MMPMID32529358
Ramcharan T
; Nolan O
; Lai CY
; Prabhu N
; Krishnamurthy R
; Richter AG
; Jyothish D
; Kanthimathinathan HK
; Welch SB
; Hackett S
; Al-Abadi E
; Scholefield BR
; Chikermane A
Pediatr Cardiol
2020[Oct]; 41
(7
): 1391-1401
PMID32529358
show ga
Children were relatively spared during COVID-19 pandemic. However, the recently
reported hyperinflammatory syndrome with overlapping features of Kawasaki disease
and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally
associated with SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac
findings and short-term outcomes in children with PIMS-TS at a tertiary
children's hospital. Single-center observational study of children with PIMS-TS
from 10th April to 9th May 2020. Data on ECG and echocardiogram were
retrospectively analyzed along with demographics, clinical features and blood
parameters. Fifteen children with median age of 8.8 (IQR 6.4-11.2) years were
included, all were from African/Afro-Caribbean, South Asian, Mixed or other
minority ethnic groups. All showed raised inflammatory/cardiac markers (CRP,
ferritin, Troponin I, CK and pro-BNP). Transient valve regurgitation was present
in 10 patients (67%). Left Ventricular ejection fraction was reduced in 12 (80%),
fractional shortening in 8 (53%) with resolution in all but 2. Fourteen (93%) had
coronary artery abnormalities, with normalization in 6. ECG abnormalities were
present in 9 (60%) which normalized in 6 by discharge. Ten (67%) needed inotropes
and/or vasopressors. None needed extracorporeal life support. Improvement in
cardiac biochemical markers was closely followed by improvement in
ECG/echocardiogram. All patients were discharged alive and twelve (80%) have been
reviewed since. Our entire cohort with PIMS-TS had cardiac involvement and this
degree of involvement is significantly more than other published series and
emphasizes the need for specialist cardiac review. We believe that our
multi-disciplinary team approach was crucial for the good short-term outcomes.