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2020 ; 10
(4
): 171-186
Nephropedia Template TP
gab.com Text
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English Wikipedia
Natural Products as Potential Leads Against Coronaviruses: Could They be
Encouraging Structural Models Against SARS-CoV-2?
#MMPMID32529545
Orhan IE
; Senol Deniz FS
Nat Prod Bioprospect
2020[Aug]; 10
(4
): 171-186
PMID32529545
show ga
New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19)
declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease
with severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2).
SARS-CoV-2 is akin to SARS-CoV, which was the causative agent of severe acute
respiratory syndrome (SARS) in 2002 as well as to that of Middle East respiratory
syndrome (MERS) in 2012. SARS-CoV-2 has been revealed to belong to Coronaviridiae
family as a member of ?-coronaviruses. It has a positive-sense single-stranded
RNA with the largest RNA genome. Since its genomic sequence has a notable
similarity to that of SARS-CoV, antiviral drugs used to treat SARS and MERS are
now being also applied for COVID-19 treatment. In order to combat SARS-CoV-2,
many drug and vaccine development studies at experimental and clinical levels are
currently conducted worldwide. In this sense, medicinal plants and the pure
natural molecules isolated from plants have been reported to exhibit significant
inhibitory antiviral activity against SARS-CoV and other types of coronaviruses.
In the present review, plant extracts and natural molecules with the mentioned
activity are discussed in order to give inspiration to researchers to take these
molecules into consideration against SARS-CoV-2.