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10.3390/ma13102393 http://scihub22266oqcxt.onion/10.3390/ma13102393 C7287629!7287629!32455965     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Materials+(Basel) 2020 ; 13 (10): ä Nephropedia Template TP {{tp|p=32455965|t=2020. Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives?Biological Activity towards Cancer Cells |pdf=|usr=}}{{32455965}} gab.com Text Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives Biological Activity towards Cancer Cells JO: Materials (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32455965 #FOAvip In the search for new antitumor agents, aminophosphonic acids and their derivatives based on octahydroquinoxalin-2(1H)-one scaffold were obtained and their cytotoxic properties and a mechanism of action were evaluated. Phosphonic acid and phosphonate moieties increased the antiproliferative activity in comparison to phenolic Mannich bases previously reported. Most of the obtained compounds revealed a strong antiproliferative effect against leukemia cell line (MV-4-11) with simultaneous low cytotoxicity against normal cell line (mouse fibroblasts-BALB/3T3). The most active compound was diphenyl-[(1R,6R)-3-oxo-2,5-diazabicyclo[4.4.0]dec-4-yl]phosphonate. Preliminary evaluation of the mechanism of action showed the proapoptotic effect associated with caspase 3/7 induction. Twit Text FOAVip Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives Biological Activity towards Cancer Cells ????Materials (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32455965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32455965 #FOAvip English Wikipedia <ref>{{Cite pmid|32455965}}</ref> Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives?Biological Activity towards Cancer Cells #MMPMID32455965 Iwanejko J; Wojaczy?ska E; Turlej E; Maciejewska M; Wietrzyk J Materials (Basel) 2020[May]; 13 (10): ä PMID32455965show ga In the search for new antitumor agents, aminophosphonic acids and their derivatives based on octahydroquinoxalin-2(1H)-one scaffold were obtained and their cytotoxic properties and a mechanism of action were evaluated. Phosphonic acid and phosphonate moieties increased the antiproliferative activity in comparison to phenolic Mannich bases previously reported. Most of the obtained compounds revealed a strong antiproliferative effect against leukemia cell line (MV-4-11) with simultaneous low cytotoxicity against normal cell line (mouse fibroblasts-BALB/3T3). The most active compound was diphenyl-[(1R,6R)-3-oxo-2,5-diazabicyclo[4.4.0]dec-4-yl]phosphonate. Preliminary evaluation of the mechanism of action showed the proapoptotic effect associated with caspase 3/7 induction. äOctahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their De(epmc).pdf DeepDyve Pubget Overpricing