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On the evolutionary epidemiology of SARS-CoV-2
#MMPMID32750338
Day T
; Gandon S
; Lion S
; Otto SP
Curr Biol
2020[Aug]; 30
(15
): R849-R857
PMID32750338
show ga
There is no doubt that the novel coronavirus SARS-CoV-2 that causes COVID-19 is
mutating and thus has the potential to adapt during the current pandemic. Whether
this evolution will lead to changes in the transmission, the duration, or the
severity of the disease is not clear. This has led to considerable scientific and
media debate, from raising alarms about evolutionary change to dismissing it.
Here we review what little is currently known about the evolution of SARS-CoV-2
and extend existing evolutionary theory to consider how selection might be acting
upon the virus during the COVID-19 pandemic. Although there is currently no
definitive evidence that SARS-CoV-2 is undergoing further adaptation, continued
evidence-based analysis of evolutionary change is important so that public health
measures can be adjusted in response to substantive changes in the infectivity or
severity of COVID-19.
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