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COVID-19 Vaccines: A Race Against Time in the Middle of Death and Devastation!
#MMPMID32837093
Khuroo MS
; Khuroo M
; Khuroo MS
; Sofi AA
; Khuroo NS
J Clin Exp Hepatol
2020[Nov]; 10
(6
): 610-621
PMID32837093
show ga
The coronavirus disease 2019 (COVID-19) has turned into a global human tragedy
and economic devastation. Governments have implemented lockdown measures, blocked
international travel, and enforced other public containment measures to mitigate
the virus morbidity and mortality. As of today, no drug has the power to fight
the infection and bring normalcy to the utter chaos. This leaves us with only one
choice namely an effective and safe vaccine that shall be manufactured as soon as
possible and available to all countries and populations affected by the pandemic
at an affordable price. There has been an unprecedented fast track path taken in
Research & Development by the World community for developing an effective and
safe vaccine. Platform technology has been exploited to develop candidate
vaccines in a matter of days to weeks, and as of now, 108 such vaccines are
available. Six of these vaccines have entered clinical trials. As clinical trials
are "rate-limiting" and "time-consuming", many innovative methods are in practice
for a fast track. These include parallel phase I-II trials and obtaining efficacy
data from phase IIb trials. Human "challenge experiments" to confirm efficacy in
humans is under serious consideration. The availability of the COVID-19 vaccine
has become a race against time in the middle of death and devastation. There is
an atmosphere of tremendous hype around the COVID-19 vaccine, and developers are
using every moment to make claims, which remain unverified. However, concerns are
raised about a rush to deploy a COVID-19 vaccine. Applying "Quick fix" and "short
cuts" can lead to errors with disastrous consequences.
free
free
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