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2020 ; 52
(9
): 659-661
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gab.com Text
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A case report of serious haemolysis in a glucose-6-phosphate
dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine
#MMPMID32496938
Maillart E
; Leemans S
; Van Noten H
; Vandergraesen T
; Mahadeb B
; Salaouatchi MT
; De Bels D
; Clevenbergh P
Infect Dis (Lond)
2020[Sep]; 52
(9
): 659-661
PMID32496938
show ga
While the COVID-19 epidemic occurred since December 2019, as of end April 2020,
no treatment has been validated or invalidated by accurate clinical trials. Use
of hydroxychloroquine has been popularised on mass media and put forward as a
valid treatment option without strong evidence of efficacy. Hydroxychloroquine
(HCQ) has its own side effects, some of which are very serious like acute
haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Side
effects may be worse than the disease itself. Belgian national treatment
guidelines recommend the use of HCQ in mild to severe COVID-19 disease. As
opinions, politics, media and beliefs are governing COVID-19 therapy, performance
of randomised controlled blinded clinical trials became difficult. Results of
sound clinical trials are eagerly awaited. We report a case of acute haemolysis
leading to admission in intensive care unit and renal failure in a patient with
uncovered G6PD deficiency.