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10.1002/phar.2429 http://scihub22266oqcxt.onion/10.1002/phar.2429 C7283864!7283864 !32446287     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32446287 &cmd=llinks): Failed to open stream: HTTP request failed! 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Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19 |pdf=|usr=}}{{32446287 }} gab.com Text Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19 JO: Pharmacotherapy http://www.kidney.de/pget.php?&tw=1&pmid=32446287 #FOAvip The global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created an urgent need for effective antivirals. Remdesivir (formerly GS-5734) is a nucleoside analogue pro-drug currently being evaluated in COVID-19 clinical trials. Its unique structural features allow high concentrations of the active triphosphate metabolite to be delivered intracellularly and it evades proofreading to successfully inhibit viral RNA synthesis. In pre-clinical models, remdesivir has demonstrated potent antiviral activity against diverse human and zoonotic ?-coronaviruses, including SARS-CoV-2. In this article, we critically review available data on remdesivir with an emphasis on biochemistry, pharmacology, pharmacokinetics, and in vitro activity against coronaviruses as well as clinical experience and current progress in COVID-19 clinical trials. Twit Text FOAVip Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19 ????Pharmacotherapy http://www.kidney.de/pget.php?&tw=1&pmid=32446287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32446287 #FOAvip English Wikipedia <ref>{{Cite pmid|32446287 }}</ref> Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19 #MMPMID32446287 Jorgensen SCJ ; Kebriaei R ; Dresser LD Pharmacotherapy 2020[Jul]; 40 (7 ): 659-671 PMID32446287 show ga The global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created an urgent need for effective antivirals. Remdesivir (formerly GS-5734) is a nucleoside analogue pro-drug currently being evaluated in COVID-19 clinical trials. Its unique structural features allow high concentrations of the active triphosphate metabolite to be delivered intracellularly and it evades proofreading to successfully inhibit viral RNA synthesis. In pre-clinical models, remdesivir has demonstrated potent antiviral activity against diverse human and zoonotic ?-coronaviruses, including SARS-CoV-2. In this article, we critically review available data on remdesivir with an emphasis on biochemistry, pharmacology, pharmacokinetics, and in vitro activity against coronaviruses as well as clinical experience and current progress in COVID-19 clinical trials. |Adenosine Monophosphate/administration & dosage/*analogs & derivatives/pharmacokinetics/pharmacology [MESH] |Alanine/administration & dosage/*analogs & derivatives/pharmacokinetics/pharmacology [MESH] |Animals [MESH] |Antiviral Agents/*administration & dosage/pharmacokinetics/pharmacology [MESH] |Betacoronavirus/drug effects/isolation & purification [MESH] |COVID-19 [MESH] |COVID-19 Drug Treatment [MESH] |Coronavirus Infections/*drug therapy/virology [MESH] |Humans [MESH] |Pandemics [MESH] |Pneumonia, Viral/*drug therapy/virology [MESH]Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Cl(epmc).pdf DeepDyve Pubget Overpricing