Potential role of platelets in COVID-19: Implications for thrombosis
#MMPMID32685881
Koupenova M
Res Pract Thromb Haemost
2020[Jul]; 4
(5
): 737-740
PMID32685881
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For the past 150 years, platelets have been recognized as the major blood
component that mediates hemostasis and thrombosis. In more recent years, however,
we have come to appreciate that platelets also perform profound immune functions
during infection with various pathogens. We now recognize that platelets can also
mediate a response to various RNA viruses such as influenza and that many viral
infections, including severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased
coagulation have been independently associated with increased mortality. This
article provides a perspective on the potential roles of platelets during
coronavirus disease 2019.