Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32775837
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Epidemiological, Clinical, and Immunological Features of a Cluster of
COVID-19-Contracted Hemodialysis Patients
#MMPMID32775837
Ma Y
; Diao B
; Lv X
; Zhu J
; Chen C
; Liu L
; Zhang S
; Shen B
; Wang H
Kidney Int Rep
2020[Aug]; 5
(8
): 1333-1341
PMID32775837
show ga
BACKGROUND: The outbreak of highly contagious coronavirus disease 2019 (COVID-19)
has posed a serious threat to human life and health, especially for those with
underlying diseases. However, the impact of COVID-19 epidemic on hemodialysis
(HD) centers and HD patients has not been reported. METHODS: We reviewed the
whole course of the COVID-19 in the HD center of Renmin Hospital, Wuhan
University (from January 14, 2020, to March 12, 2020). We compared the clinical
manifestation and immune profiles among different patient groups with healthy
individuals. RESULTS: Forty-two of 230 HD patients (18.26%) and 4 of 33 medical
staff (12.12%) were diagnosed with COVID-19 during the study period. Fifteen HD
patients (6.52%), including 10 COVID-19 diagnosed, died. Only 2 deaths of the
COVID-19 HD patients were associated with pneumonia/lung failure, others were
ascribed to cardiovascular/cerebrovascular diseases or hyperkalemia. Except for 3
patients who were admitted to the intensive care unit for a severe condition
(8.11%), including 2 who died, most COVID-19 diagnosed patients presented mild or
nonrespiratory symptoms. The flow cytometric analysis of peripheral blood showed
that multiple lymphocyte populations in HD patients were significantly decreased.
HD patients with COVID-19 even displayed more remarkable reduction of serum
inflammatory cytokines than other patients with COVID-19. CONCLUSIONS: Compared
with the general population, HD patients and health care professionals are the
highly susceptible population and HD centers are high-risk areas during the
outbreak. Most HD patients with COVID-19 exhibited mild clinical symptoms and did
not progress to severe pneumonia, likely due to the impaired cellular immune
function and incapability of mounting cytokine storm. More attention should be
paid to prevent cardiovascular events, which may be the collateral impacts of the
COVID-19 epidemic on HD patients.
free
free
free
