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10.1002/jmv.26045 http://scihub22266oqcxt.onion/10.1002/jmv.26045 C7280739!7280739 !32441816     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32441816 &cmd=llinks): Failed to open stream: HTTP request failed! 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Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2 |pdf=|usr=}}{{32441816 }} gab.com Text Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32441816 #FOAvip Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused severe health threats and fatalities in almost all communities. Studies have detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva with a viral load that lasts for a long period. However, researchers are yet to establish whether SARS-CoV-2 can directly enter the salivary glands. Therefore, this study aimed to assess the presence of angiotensin-converting enzyme 2 (ACE2)/transmembrane serine proteases 2 (TMPRSS2) expression in salivary glands using publicly available databases. The distribution of ACE2 and TMPRSSs family in salivary gland tissue and other tissues was analyzed. The Genotype-Tissue Expression dataset was employed to explore the ACE2 and TMPRSS2 expression in various body organs and salivary glands in a healthy population. The single-cell sequencing data for salivary gland samples (including submandibular salivary gland and parotid gland) from mice were collected and analyzed. The components and proportions of salivary gland cells expressing the key protease TMPRSSs family were analyzed. Transcriptome data analysis showed that ACE2 and TMPRSS2 were expressed in salivary glands. The expression levels of ACE2 and TMPRSS2 were marginal without significant differences in different age groups or between men and women. Single-cell RNA sequence analysis indicated that TMPRSS2 was mainly expressed in salivary gland epithelial cells. We speculate that SARS-CoV-2 may be entered in salivary glands. Twit Text FOAVip Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32441816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32441816 #FOAvip English Wikipedia <ref>{{Cite pmid|32441816 }}</ref> Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2 #MMPMID32441816 Song J ; Li Y ; Huang X ; Chen Z ; Li Y ; Liu C ; Chen Z ; Duan X J Med Virol 2020[Nov]; 92 (11 ): 2556-2566 PMID32441816 show ga Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused severe health threats and fatalities in almost all communities. Studies have detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva with a viral load that lasts for a long period. However, researchers are yet to establish whether SARS-CoV-2 can directly enter the salivary glands. Therefore, this study aimed to assess the presence of angiotensin-converting enzyme 2 (ACE2)/transmembrane serine proteases 2 (TMPRSS2) expression in salivary glands using publicly available databases. The distribution of ACE2 and TMPRSSs family in salivary gland tissue and other tissues was analyzed. The Genotype-Tissue Expression dataset was employed to explore the ACE2 and TMPRSS2 expression in various body organs and salivary glands in a healthy population. The single-cell sequencing data for salivary gland samples (including submandibular salivary gland and parotid gland) from mice were collected and analyzed. The components and proportions of salivary gland cells expressing the key protease TMPRSSs family were analyzed. Transcriptome data analysis showed that ACE2 and TMPRSS2 were expressed in salivary glands. The expression levels of ACE2 and TMPRSS2 were marginal without significant differences in different age groups or between men and women. Single-cell RNA sequence analysis indicated that TMPRSS2 was mainly expressed in salivary gland epithelial cells. We speculate that SARS-CoV-2 may be entered in salivary glands. |Adult [MESH] |Age Factors [MESH] |Angiotensin-Converting Enzyme 2/*genetics [MESH] |Animals [MESH] |COVID-19/*transmission/virology [MESH] |Computational Biology [MESH] |Correlation of Data [MESH] |Databases, Factual [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Parotid Gland/virology [MESH] |Peptidyl-Dipeptidase A/*genetics [MESH] |SARS-CoV-2/pathogenicity [MESH] |Salivary Glands/*virology [MESH] |Sequence Analysis, RNA [MESH] |Serine Endopeptidases/*genetics [MESH] |Sex Factors [MESH]Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands (epmc).pdf DeepDyve Pubget Overpricing