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2020 ; 92
(11
): 2528-2535
Nephropedia Template TP
gab.com Text
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English Wikipedia
Epidemiological and clinical characteristics of discharged patients infected with
SARS-CoV-2 on the Qinghai Plateau
#MMPMID32437017
Xi A
; Zhuo M
; Dai J
; Ding Y
; Ma X
; Ma X
; Wang X
; Shi L
; Bai H
; Zheng H
; Nuermberger E
; Xu J
J Med Virol
2020[Nov]; 92
(11
): 2528-2535
PMID32437017
show ga
Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in
Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet
plateau. We aimed to describe the epidemiological, clinical characteristics, and
outcomes of all confirmed cases in Qinghai, a province at high altitude. The
region had no sustained local transmission. Of all 18 patients with confirmed
SARS-CoV-2 infection, 15 patients comprising four transmission clusters were
identified. Three patients were infected by direct contact without travel history
to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients
showed no abnormalities. Three patients with comorbidities such as hypertension,
liver diseases, or diabetes developed severe illness. High C-reactive protein
levels and elevations of both alanine aminotransferase and aspartate
aminotransferase were observed in three severely ill patients on admission. All
18 patients were eventually discharged, including the three severe patients who
recovered after treatment with noninvasive mechanical ventilation, convalescent
plasma, and other therapies. Our findings confirmed human-to-human transmission
of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop
severe illness.