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2020 ; 21
(10
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System
and Their Role in Lung Homeostasis
#MMPMID32466119
Cañadas O
; Olmeda B
; Alonso A
; Pérez-Gil J
Int J Mol Sci
2020[May]; 21
(10
): ä PMID32466119
show ga
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar
epithelium and secreted into the airspaces, where it coats and protects the large
respiratory air-liquid interface. Surfactant, assembled as a complex network of
membranous structures, integrates elements in charge of reducing surface tension
to a minimum along the breathing cycle, thus maintaining a large surface open to
gas exchange and also protecting the lung and the body from the entrance of a
myriad of potentially pathogenic entities. Different molecules in the surfactant
establish a multivalent crosstalk with the epithelium, the immune system and the
lung microbiota, constituting a crucial platform to sustain homeostasis, under
health and disease. This review summarizes some of the most important molecules
and interactions within lung surfactant and how multiple lipid-protein and
protein-protein interactions contribute to the proper maintenance of an operative
respiratory surface.