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10.12122/j.issn.1673-4254.2020.05.02 http://scihub22266oqcxt.onion/10.12122/j.issn.1673-4254.2020.05.02 C7277311!7277311!32897211     free     free     free       Nan+Fang+Yi+Ke+Da+Xue+Xue+Bao 2020 ; 40 (5): 616-23 Nephropedia Template TP {{tp|p=32897211|t=2020. ???????????????????????COVID-19??? |pdf=|usr=}}{{32897211}} gab.com Text COVID-19 JO: Nan Fang Yi Ke Da Xue Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=32897211 #FOAvip Objective: To explore the target, signaling pathways and their biological functions of QingfeiPaidu Decoction in the treatment of COVID-19 based on network pharmacology and molecular docking technology. Methods: The active components and target proteins in 21 drugs such as EphedraeHerba and PinelliaeRhizoma in QingfeiPaidu decoction were analyzed, and the signaling pathways and biological functions of the target proteins common with COVID-19 were screened by using TCMSP, Swiss Target Prediction, CooLGeN, GeneCards, DAVID and other databases. The network diagram of QingfeiPaidu decoction was constructed using Gephi software. Results: We identified 163 active ingredients, including MOL004798, MOL000519, MOL004824, MOL000554, MOL010428, and MOL013443, from 18 drugs in QingfeiPaidu decoction (such as EphedraeHerba, PinelliaeRhizoma, GlycyrrhizaeRadixEtRhiizoma, FarfaraeFlos, AsterisRadixEtRhizoma and AurantiiFructusImmaturus). These ingredients activate renin-angiotensin system signaling pathway and apoptosis signaling pathway by regulating 10 protein targets (ACE, ACE2, AGTR1, FURIN, TNF, CASP3, CASP6, DPP4, MCL1 and POLD1) to execute 42 biological functions such as renin-angiotensin regulation of blood volume and systemic arterial blood pressure to treat COVID-19. The results of preliminary molecular docking showed that MOL000519 (from PinelliaeRhizoma), MOL000554 (from FarfaraeFlos), MOL004798 (from EphedraeHerba), MOL004824 (from GlycyrrhizaeRadixEtRhiizoma), MOL010428 (from AsterisRadixEtRhizoma), and MOL013443 (from AurantiiFructusImmaturus) had good affinity with SARS-CoV-2 3CL hydrolase to form complexes with stable conformations and high binding activity (binding energy ?- 5 kJ/mol). Conclusion: QingfeiPaidu decoction can treat COVID-19 through its multiple medicinal ingredients that have multiple targets and involve multiple signaling pathways for different biological functions. Our finding provides reference for further investigation into the pharmacological mechanism of QingfeiPaidu decoction in treating COVID-19. Twit Text FOAVip COVID-19 ????Nan Fang Yi Ke Da Xue Xue Bao http://www.kidney.de/pget.php?&tw=1&pmid=32897211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32897211 #FOAvip English Wikipedia <ref>{{Cite pmid|32897211}}</ref> ???????????????????????COVID-19??? #MMPMID32897211 ä Nan Fang Yi Ke Da Xue Xue Bao 2020[May]; 40 (5): 616-23 PMID32897211show ga Objective: To explore the target, signaling pathways and their biological functions of QingfeiPaidu Decoction in the treatment of COVID-19 based on network pharmacology and molecular docking technology. Methods: The active components and target proteins in 21 drugs such as EphedraeHerba and PinelliaeRhizoma in QingfeiPaidu decoction were analyzed, and the signaling pathways and biological functions of the target proteins common with COVID-19 were screened by using TCMSP, Swiss Target Prediction, CooLGeN, GeneCards, DAVID and other databases. The network diagram of QingfeiPaidu decoction was constructed using Gephi software. Results: We identified 163 active ingredients, including MOL004798, MOL000519, MOL004824, MOL000554, MOL010428, and MOL013443, from 18 drugs in QingfeiPaidu decoction (such as EphedraeHerba, PinelliaeRhizoma, GlycyrrhizaeRadixEtRhiizoma, FarfaraeFlos, AsterisRadixEtRhizoma and AurantiiFructusImmaturus). These ingredients activate renin-angiotensin system signaling pathway and apoptosis signaling pathway by regulating 10 protein targets (ACE, ACE2, AGTR1, FURIN, TNF, CASP3, CASP6, DPP4, MCL1 and POLD1) to execute 42 biological functions such as renin-angiotensin regulation of blood volume and systemic arterial blood pressure to treat COVID-19. The results of preliminary molecular docking showed that MOL000519 (from PinelliaeRhizoma), MOL000554 (from FarfaraeFlos), MOL004798 (from EphedraeHerba), MOL004824 (from GlycyrrhizaeRadixEtRhiizoma), MOL010428 (from AsterisRadixEtRhizoma), and MOL013443 (from AurantiiFructusImmaturus) had good affinity with SARS-CoV-2 3CL hydrolase to form complexes with stable conformations and high binding activity (binding energy ?- 5 kJ/mol). Conclusion: QingfeiPaidu decoction can treat COVID-19 through its multiple medicinal ingredients that have multiple targets and involve multiple signaling pathways for different biological functions. Our finding provides reference for further investigation into the pharmacological mechanism of QingfeiPaidu decoction in treating COVID-19. ä???????????????????????COVID-19??? (epmc).pdf DeepDyve Pubget Overpricing