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10.1016/j.xcrm.2020.100040 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100040 C7276302!7276302!32835303     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (3): ä Nephropedia Template TP {{tp|p=32835303|t=2020. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients |pdf=|usr=}}{{32835303}} gab.com Text Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32835303 #FOAvip SARS-CoV-2, the virus responsible for COVID-19, is causing a devastating worldwide pandemic, and there is a pressing need to understand the development, specificity, and neutralizing potency of humoral immune responses during acute infection. We report a cross-sectional study of antibody responses to the receptor-binding domain (RBD) of the spike protein and virus neutralization activity in a cohort of 44 hospitalized COVID-19 patients. RBD-specific IgG responses are detectable in all patients 6 days after PCR confirmation. Isotype switching to IgG occurs rapidly, primarily to IgG1 and IgG3. Using a clinical SARS-CoV-2 isolate, neutralizing antibody titers are detectable in all patients by 6 days after PCR confirmation and correlate with RBD-specific binding IgG titers. The RBD-specific binding data were further validated in a clinical setting with 231 PCR-confirmed COVID-19 patient samples. These findings have implications for understanding protective immunity against SARS-CoV-2, therapeutic use of immune plasma, and development of much-needed vaccines. Twit Text FOAVip Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32835303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32835303 #FOAvip English Wikipedia <ref>{{Cite pmid|32835303}}</ref> Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients #MMPMID32835303 Suthar MS; Zimmerman MG; Kauffman RC; Mantus G; Linderman SL; Hudson WH; Vanderheiden A; Nyhoff L; Davis CW; Adekunle O; Affer M; Sherman M; Reynolds S; Verkerke HP; Alter DN; Guarner J; Bryksin J; Horwath MC; Arthur CM; Saakadze N; Smith GH; Edupuganti S; Scherer EM; Hellmeister K; Cheng A; Morales JA; Neish AS; Stowell SR; Frank F; Ortlund E; Anderson EJ; Menachery VD; Rouphael N; Mehta AK; Stephens DS; Ahmed R; Roback JD; Wrammert J Cell Rep Med 2020[Jun]; 1 (3): ä PMID32835303show ga SARS-CoV-2, the virus responsible for COVID-19, is causing a devastating worldwide pandemic, and there is a pressing need to understand the development, specificity, and neutralizing potency of humoral immune responses during acute infection. We report a cross-sectional study of antibody responses to the receptor-binding domain (RBD) of the spike protein and virus neutralization activity in a cohort of 44 hospitalized COVID-19 patients. RBD-specific IgG responses are detectable in all patients 6 days after PCR confirmation. Isotype switching to IgG occurs rapidly, primarily to IgG1 and IgG3. Using a clinical SARS-CoV-2 isolate, neutralizing antibody titers are detectable in all patients by 6 days after PCR confirmation and correlate with RBD-specific binding IgG titers. The RBD-specific binding data were further validated in a clinical setting with 231 PCR-confirmed COVID-19 patient samples. These findings have implications for understanding protective immunity against SARS-CoV-2, therapeutic use of immune plasma, and development of much-needed vaccines. äRapid Generation of Neutralizing Antibody Responses in COVID-19 Patien(epmc).pdf DeepDyve Pubget Overpricing