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10.1016/j.xkme.2020.05.004

http://scihub22266oqcxt.onion/10.1016/j.xkme.2020.05.004
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C7275990!7275990!32775989
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suck abstract from ncbi


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pmid32775989      Kidney+Med 2020 ; 2 (4): 488-92
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  • COVID-19?Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis #MMPMID32775989
  • Magoon S; Bichu P; Malhotra V; Alhashimi F; Hu Y; Khanna S; Berhanu K
  • Kidney Med 2020[Jul]; 2 (4): 488-92 PMID32775989show ga
  • Coronavirus disease 19 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with acute kidney injury, presumably due to acute tubular injury. However, this does not explain proteinuria, sometimes severe, and hematuria often observed. We present 2 African American patients with glomerulopathy demonstrated by kidney biopsy in the setting of acute kidney injury and COVID-19 infection. Kidney biopsy specimens showed a collapsing variant of focal segmental glomerulosclerosis in addition to acute tubular injury. Both patients were homozygous for apolipoprotein L1 (APOL1). COVID-19 infection likely caused the interferon surge as a second hit causing podocyte injury leading to collapsing focal segmental glomerulosclerosis. APOL1 testing should be strongly considered in African American patients with nephrotic-range proteinuria. More data from future kidney biopsies will further elucidate the pathology of kidney injury and glomerular involvement from COVID-19 infections.
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