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Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and
Meta-analysis
#MMPMID32753137
Agyeman AA
; Chin KL
; Landersdorfer CB
; Liew D
; Ofori-Asenso R
Mayo Clin Proc
2020[Aug]; 95
(8
): 1621-1631
PMID32753137
show ga
OBJECTIVE: To estimate the prevalence of olfactory and gustatory dysfunctions
(OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19).
METHODS: A systematic review was conducted by searching MEDLINE, EMBASE, and the
preprint server MedRxiv from their inception until May 11, 2020, using the terms
anosmia or hyposmia or dysosmia or olfactory dysfunction or olfaction disorder or
smell dysfunction or ageusia or hypogeusia or dysgeusia or taste dysfunction or
gustatory dysfunction or neurological and COVID-19 or 2019 novel coronavirus or
2019-nCoV or SARS-CoV-2. The references of included studies were also manually
screened. Only studies involving patients with diagnostic-confirmed COVID-19
infection were included. Random-effects meta-analysis was performed. RESULTS:
Twenty-four studies with data from 8438 patients with test-confirmed COVID-19
infection from 13 countries were included. The pooled proportions of patients
presenting with olfactory dysfunction and gustatory dysfunction were 41.0% (95%
CI, 28.5% to 53.9%) and 38.2% (95% CI, 24.0% to 53.6%), respectively. Increasing
mean age correlated with lower prevalence of olfactory (coefficient = -0.076;
P=.02) and gustatory (coefficient = -0.073; P=.03) dysfunctions. There was a
higher prevalence of olfactory dysfunctions with the use of objective
measurements compared with self-reports (coefficient = 2.33; P=.01). No
significant moderation of the prevalence of OGDs by sex was observed. CONCLUSION:
There is a high prevalence of OGDs among patients infected with COVID-19. Routine
screening for these conditions could contribute to improved case detection in the
ongoing COVID-19 pandemic. However, to better inform population screening
measures, further studies are needed to establish causality.
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