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10.1017/cts.2020.39

http://scihub22266oqcxt.onion/10.1017/cts.2020.39
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C7274027!7274027!C7274027
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suck abstract from ncbi


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  • The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development #MMPMIDC7274027
  • Wang J; Zand MS
  • J Clin Transl Sci ä[]; ä (ä): 1-4 PMIDC7274027show ga
  • There is an urgent need for vaccines to the 2019 coronavirus (COVID19; SARS-CoV-2). Vaccine development may not be straightforward, due to antibody-dependent enhancement (ADE). Antibodies against viral surface proteins can, in some cases, increase infection severity by ADE. This phenomenon occurs in SARS-CoV-1, MERS, HIV, Zika, and dengue virus infection and vaccination. Lack of high-affinity anti-SARS-CoV-2 IgG in children may explain the decreased severity of infection in these groups. Here, we discuss the evidence for ADE in the context of SARS-CoV-2 infection and how to address this potential translational barrier to vaccine development, convalescent plasma, and targeted monoclonal antibody therapies.
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