Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32837537
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Cross-species transmission of deltacoronavirus and the origin of porcine
deltacoronavirus
#MMPMID32837537
Ye X
; Chen Y
; Zhu X
; Guo J
; Xie D
; Hou Z
; Xu S
; Zhou J
; Fang L
; Wang D
; Xiao S
Evol Appl
2020[Oct]; 13
(9
): 2246-2253
PMID32837537
show ga
Deltacoronavirus is the last identified Coronaviridae subfamily genus. Differing
from other coronavirus (CoV) genera, which mainly infect birds or mammals,
deltacoronaviruses (?-CoVs) reportedly infect both animal types. Recent studies
show that a novel ?-CoV, porcine deltacoronavirus (PDCoV), can also infect calves
and chickens with the potential to infect humans, raising the possibility of
cross-species transmission of ?-CoVs. Here, we explored the deep phylogenetic
history and cross-species transmission of ?-CoVs. Virus-host cophylogenetic
analyses showed that ?-CoVs have undergone frequent host switches in birds, and
sparrows may serve as the unappreciated hubs for avian to mammal transmission.
Our molecular clock analyses show that PDCoV possibly originated in Southeast
Asia in the 1990s and that the PDCoV cluster shares a common ancestor with
Sparrow-CoV of around 1,810. Our findings contribute valuable insights into the
diversification, evolution, and interspecies transmission of ?-CoVs and the
origin of PDCoV, providing a model for exploring the relationships of ?-CoVs in
birds and mammals.
free
free
free
