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2020 ; 23
(6
): 784-788
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
The Use of Non-invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms
Associated With COVID-19: A Theoretical Hypothesis and Early Clinical Experience
#MMPMID32342609
Staats P
; Giannakopoulos G
; Blake J
; Liebler E
; Levy RM
Neuromodulation
2020[Aug]; 23
(6
): 784-788
PMID32342609
show ga
OBJECTIVES: Coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic with no specific
therapeutic agents and substantial mortality, and finding new treatments is
critical. Most cases are mild, but a significant minority of patients develop
moderate to severe respiratory symptoms, with the most severe cases requiring
intensive care and/or ventilator support. This respiratory compromise appears to
be due to a hyperimmune reaction, often called a cytokine storm. Vagus nerve
stimulation has been demonstrated to block production of cytokines in sepsis and
other medical conditions. We hypothesize that non-invasive vagus nerve
stimulation (nVNS) might provide clinical benefits in patients with respiratory
symptoms similar to those associated with COVID-19. MATERIALS AND METHODS:
Information on two case reports was obtained via email correspondence and phone
interviews with the patients. RESULTS: Both patients reported clinically
meaningful benefits from nVNS therapy. In case 1, the patient used nVNS to
expedite symptomatic recovery at home after hospital discharge and was able to
discontinue use of opioid and cough suppressant medications. In case 2, the
patient experienced immediate and consistent relief from symptoms of chest
tightness and shortness of breath, as well as an improved ability to clear his
lungs. CONCLUSIONS: Preliminary observations and a strong scientific foundation
suggest that nVNS might provide clinical benefits in patients with COVID-19 via
multiple mechanisms.