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2020 ; 61
(6
): 1166-1173
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Severe psychological distress among patients with epilepsy during the COVID-19
outbreak in southwest China
#MMPMID32353184
Hao X
; Zhou D
; Li Z
; Zeng G
; Hao N
; Li E
; Li W
; Deng A
; Lin M
; Yan B
Epilepsia
2020[Jun]; 61
(6
): 1166-1173
PMID32353184
show ga
OBJECTIVE: To compare the severity of psychological distress between patients
with epilepsy and healthy controls during the COVID-19 outbreak in southwest
China, as well as identify potential risk factors of severe psychological
distress among patients with epilepsy. METHODS: This cross-sectional case-control
study examined a consecutive sample of patients older than 15 years treated at
the epilepsy center of West China Hospital between February 1 and February 29,
2020. As controls, sex- and age-matched healthy visitors of inpatients (unrelated
to the patients) were also enrolled during the same period. Data on demographics
and attention paid to COVID-19 were collected by online questionnaire, data on
epilepsy features were collected from electronic medical records, and
psychological distress was evaluated using the 6-item Kessler Psychological
Distress Scale (K-6). Potential risk factors of severe psychological distress
were identified using multivariate logistic regression. RESULTS: The 252 patients
and 252 controls in this study were similar along all demographic variables
except family income. Patients with epilepsy showed significantly higher K-6
scores than healthy controls and spent significantly more time following the
COVID-19 outbreak (both P < .001). Univariate analyses associated both diagnosis
of drug-resistant epilepsy and time spent paying attention to COVID-19 with
severe psychological distress (defined as K-6 score >12; both P ? .001).
Multivariate logistic regression identified two independent predictors of severe
psychological distress: time spent paying attention to COVID-19 (odds ratio [OR]
= 1.172, 95% confidence interval [CI] = 1.073-1.280) and diagnosis of
drug-resistant epilepsy (OR = 0.283, 95% CI = 0.128-0.623). SIGNIFICANCE: During
public health outbreaks, clinicians and caregivers should focus not only on
seizure control but also on mental health of patients with epilepsy, especially
those with drug-resistant epilepsy. K-6 scores > 12 indicate severe psychological
distress. This may mean, for example, encouraging patients to engage in other
activities instead of excessively following media coverage of the outbreak.