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2020 ; 85
(ä): 106654
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An approach towards development of monoclonal IgY antibodies against SARS CoV-2
spike protein (S) using phage display method: A review
#MMPMID32512271
Somasundaram R
; Choraria A
; Antonysamy M
Int Immunopharmacol
2020[Aug]; 85
(ä): 106654
PMID32512271
show ga
The present state of diagnostic and therapeutic developmental race for vaccines
against the SARS CoV-2 (nCOVID-19) focuses on prevention and control of this
global pandemic which also represents a critical challenge to the global health
community. Although development of novel vaccines can prevent the SARS CoV-2
infections, it is still impeded by several other factors and therefore novel
approaches towards treatment and management of this disease is the urgent need.
Passive immunotherapy plays a vital role as a possible alternative to meet this
challenge and among various antibody sources, chicken egg yolk antibodies (IgY)
can be used as an alternative to mammalian antibodies which have been previously
studied against SARS CoV outbreak in China. In this review, we discuss the
strategies for the use of chicken egg yolk (IgY) antibodies in the development of
rapid diagnosis and immunotherapy against SARS CoV-2. Also, IgY antibodies have
previously been used against various respiratory bacterial and viral infections
in humans and animals. Compared to mammalian antibodies (IgG), chicken egg yolk
antibodies (IgY) have greater binding affinity to specific antigens, ease of
extraction and lower production costs, hence possessing remarkable
pathogen-neutralizing activity of pathogens in respiratory and lungs. We provide
an overall importance for the use of monoclonal chicken egg yolk antibodies (IgY)
using phage display method describing their potential passive immunotherapeutic
application for the treatment and prevention of SARS CoV-2 infection which is
simple, fast and safe way of approach for treating patients effectively.