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2020 ; 33
(3
): 366-369
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Meta-analysis of outcomes of patients with COVID-19 infection with versus without
gastrointestinal symptoms
#MMPMID32669979
Gul F
; Lo KB
; Peterson J
; McCullough PA
; Goyal A
; Rangaswami J
Proc (Bayl Univ Med Cent)
2020[Jul]; 33
(3
): 366-369
PMID32669979
show ga
This systematic review analyzed whether the presence or absence of
gastrointestinal symptoms in patients with SARS-COV-2 infection is associated
with adverse outcomes. Searching the Cochrane Center Register of Controlled
Trials, we included any studies looking at patients with COVID-19 with
gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain) compared
to those with COVID-19 but without gastrointestinal manifestations as a control
group. The final search yielded 186 articles, all of which were individually
screened. Seven studies were identified but three were excluded: one due to lack
of a control group without gastrointestinal symptoms, one reported as viral RNA
in the stool, and one with only non-critically ill patients. Results of the
meta-analysis showed a pooled odds ratio for mortality among those with COVID-19
and gastrointestinal symptoms of 0.91 (confidence interval 0.49-1.68) with
heterogeneity of 0% and a pooled odds ratio for acute respiratory distress
syndrome of 2.94 (confidence interval 1.17-7.40) with heterogeneity of 0%. In
conclusion, gastrointestinal symptoms with COVID-19 are associated with a higher
risk of acute respiratory distress syndrome, but do not increase the risk for
mortality.