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10.1016/j.gendis.2020.05.006 http://scihub22266oqcxt.onion/10.1016/j.gendis.2020.05.006 C7264919!7264919 !32837981     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32837981 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Genes+Dis 2020 ; 7 (4 ): 567-577 Nephropedia Template TP {{tp|p=32837981 |t=2020. Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains |pdf=|usr=}}{{32837981 }} gab.com Text Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains JO: Genes Dis http://www.kidney.de/pget.php?&tw=1&pmid=32837981 #FOAvip As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to disperse globally with worrisome speed, identifying amino acid variations in the virus could help to understand the characteristics of it. Here, we studied 489 SARS-CoV-2 genomes obtained from 32 countries from the Nextstrain database and performed phylogenetic tree analysis by clade, country, and genotype of the surface spike glycoprotein (S protein) at site 614. We found that virus strains from mainland China were mostly distributed in Clade B and Clade undefined in the phylogenetic tree, with very few found in Clade A. In contrast, Clades A2 (one case) and A2a (112 cases) predominantly contained strains from European regions. Moreover, Clades A2 and A2a differed significantly from those of mainland China in age of infected population (P = 0.0071, mean age 40.24 to 46.66), although such differences did not exist between the US and mainland China. Further analysis demonstrated that the variation of the S protein at site 614 (QHD43416.1: p.614D>G) was a characteristic of stains in Clades A2 and A2a. Importantly, this variation was predicted to have neutral or benign effects on the function of the S protein. In addition, global quality estimates and 3D protein structures tended to be different between the two S proteins. In summary, we identified different genomic epidemiology among SARS-CoV-2 strains in different clades, especially in an amino acid variation of the S protein at 614, revealing potential viral genome divergence in SARS-CoV-2 strains. Twit Text FOAVip Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains ????Genes Dis http://www.kidney.de/pget.php?&tw=1&pmid=32837981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32837981 #FOAvip English Wikipedia <ref>{{Cite pmid|32837981 }}</ref> Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains #MMPMID32837981 Canhui Cao ; Huang L ; Liu K ; Ma K ; Tian Y ; Qin Y ; Sun H ; Ding W ; Gui L ; Wu P Genes Dis 2020[Dec]; 7 (4 ): 567-577 PMID32837981 show ga As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to disperse globally with worrisome speed, identifying amino acid variations in the virus could help to understand the characteristics of it. Here, we studied 489 SARS-CoV-2 genomes obtained from 32 countries from the Nextstrain database and performed phylogenetic tree analysis by clade, country, and genotype of the surface spike glycoprotein (S protein) at site 614. We found that virus strains from mainland China were mostly distributed in Clade B and Clade undefined in the phylogenetic tree, with very few found in Clade A. In contrast, Clades A2 (one case) and A2a (112 cases) predominantly contained strains from European regions. Moreover, Clades A2 and A2a differed significantly from those of mainland China in age of infected population (P = 0.0071, mean age 40.24 to 46.66), although such differences did not exist between the US and mainland China. Further analysis demonstrated that the variation of the S protein at site 614 (QHD43416.1: p.614D>G) was a characteristic of stains in Clades A2 and A2a. Importantly, this variation was predicted to have neutral or benign effects on the function of the S protein. In addition, global quality estimates and 3D protein structures tended to be different between the two S proteins. In summary, we identified different genomic epidemiology among SARS-CoV-2 strains in different clades, especially in an amino acid variation of the S protein at 614, revealing potential viral genome divergence in SARS-CoV-2 strains. ?Amino acid variation analysis of surface spike glycoprotein at 614 in (epmc).pdf DeepDyve Pubget Overpricing