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Complex Networks in Health and Disease
#MMPMIDC7263184
Vulliard L
; Menche J
Systems Medicine
2021[]; ? (?): 26-33
PMIDC7263184
show ga
From protein interactions to signal transduction, from metabolism to the nervous
system: Virtually all processes in health and disease rely on the careful
orchestration of a large number of diverse individual components ranging from
molecules to cells and entire organs. Networks provide a powerful framework for
describing and understanding these complex systems in a wholistic fashion. They
offer a unique combination of a highly intuitive, qualitative description, and a
plethora of analytical, quantitative tools. Here we provide a brief introduction
to the emerging field of network medicine. After an overview of the core concepts
for connecting network characteristics to biological functions, we review
commonly used networks, ranging from the molecular interaction networks that form
the basis of all biological processes in the cell to the global transportation
networks that govern the spread of global epidemics. Lastly, we highlight current
conceptual and practical challenges.
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