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2020 ; 135
(ä): 47-50
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Developing a risk assessment score for patients with cancer during the
coronavirus disease 2019 pandemic
#MMPMID32534244
Indini A
; Rijavec E
; Ghidini M
; Cattaneo M
; Grossi F
Eur J Cancer
2020[Aug]; 135
(ä): 47-50
PMID32534244
show ga
The novel coronavirus (CoV) pandemic is a serious threat for patients with
cancer, who have an immunocompromised status and are considered at high risk of
infections. Data on the novel CoV respiratory disease (coronavirus disease 2019
[COVID-19]) in patients with cancer are still limited. Unlike other common
viruses, CoVs have not been shown to cause a more severe disease in
immunocompromised subjects. Along with direct viral pathogenicity, in some
individuals, CoV infection triggers an uncontrolled aberrant inflammatory
response, leading to lung tissue damage. In patients with cancer treated with
immunotherapy (e.g. immune checkpoint inhibitors), COVID-19 may therefore
represent a serious threat. After a thorough review of the literature on CoV
pathogenesis and cancer, we selected several shared features to define which
patients can be considered at higher risk of COVID-19. We combined these clinical
and laboratory variables, with the aim of developing a score to weight the risk
of COVID-19 in patients with cancer.