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2020 ; 5
(ä): 346-356
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A novel IDEA: The impact of serial interval on a modified-Incidence Decay and
Exponential Adjustment (m-IDEA) model for projections of daily COVID-19 cases
#MMPMID32537527
Smith BA
Infect Dis Model
2020[]; 5
(ä): 346-356
PMID32537527
show ga
The SARS-CoV-2 virus causes the disease COVID-19, and has caused high morbidity
and mortality worldwide. Empirical models are useful tools to predict future
trends of disease progression such as COVID-19 over the near-term. A modified
Incidence Decay and Exponential Adjustment (m-IDEA) model was developed to
predict the progression of infectious disease outbreaks. The modification allows
for the production of precise daily estimates, which are critical during a
pandemic of this scale for planning purposes. The m-IDEA model was employed using
a range of serial intervals given the lack of knowledge on the true serial
interval of COVID-19. Both deterministic and stochastic approaches were applied.
Model fitting was accomplished through minimizing the sum-of-square differences
between predicted and observed daily incidence case counts, and performance was
retrospectively assessed. The performance of the m-IDEA for projection cases in
the near-term was improved using shorter serial intervals (1-4 days) at early
stages of the pandemic, and longer serial intervals at mid- to late-stages (5-9
days) thus far. This, coupled with epidemiological reports, suggests that the
serial interval of COVID-19 might increase as the pandemic progresses, which is
rather intuitive: Increasing serial intervals can be attributed to gradual
increases in public health interventions such as facility closures, public
caution and social distancing, thus increasing the time between transmission
events. In most cases, the stochastic approach captured the majority of future
reported incidence data, because it accounts for the uncertainty around the
serial interval of COVID-19. As such, it is the preferred approach for using the
m-IDEA during dynamic situation such as in the midst of a major pandemic.