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2020 ; 128
(ä): 110316
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Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by
network pharmacology tools
#MMPMID32505821
Kong Q
; Wu Y
; Gu Y
; Lv Q
; Qi F
; Gong S
; Chen X
Biomed Pharmacother
2020[Aug]; 128
(ä): 110316
PMID32505821
show ga
BACKGROUND: Pudilan (PDL), a four-herb prescription with the traditional function
of heat-clearing and detoxifying, has been clinically used as an anti-SARS-CoV-2
infectory agent in China. PDL might also have therapeutic potentials for COVID-19
while the underlying mechanisms remain to be clarified. METHODS: We used network
pharmacology analysis and selected 68 co-targeted genes/proteins as targets of
both PDL and COVID-19. These co-targeted genes/proteins were predicted by
SwissDock Server for their high-precision docking simulation, and analyzed by
STRING for proteins to protein interaction (PPI), pathway and GO (gene ontology)
enrichment. The therapeutic effect for PDL treatment on COVID-19 was validated by
the TCMATCOV (TCM Anti COVID-19) platform. RESULTS: PDL might prevent the
entrance of SARS-CoV-2 entry into cells by blocking the angiotensin-converting
enzyme 2 (ACE2). It might inhibit the cytokine storm by affecting C-reactive
protein (CRP), interferon-? (IFN-?), interleukin- 6 (IL-6), interleukin- 10
(IL-10), tumor necrosis factor (TNF), epidermal growth factor receptor (EGFR),
C-C motif chemokine ligand 5 (CCL5), transforming growth factor-?1 (TGF?1), and
other proteins. PDL might moderate the immune system to shorten the course of the
disease, delay disease progression, and reduce the mortality rate. CONCLUSION:
PDL might have a therapeutic effect on COVID-19 through three aspects, including
the moderate immune system, anti-inflammation, and anti-virus entry into cells.
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