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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+Respir+J 2020 ; 56 (1): ä Nephropedia Template TP
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What do differences in case fatality ratios between children and adults tell us about COVID-19? #MMPMID32471937
Midulla F; Cristiani L; Mancino E
Eur Respir J 2020[Jul]; 56 (1): ä PMID32471937show ga
We thank S. Ebmeier and A.J. Cunnington for their commentary on our editorial [1], providing another point of view on such a controversial topic. In their letter, S. Ebmeier and A.J. Cunnington assume that the greater burden of coronavirus disease 19 (COVID-19) in adults may be related to the absence in the population of prior immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as occurred in fully susceptible populations during previous viral epidemics. In particular, Shankset al. [2] report that the measles mortality rate in a fully susceptible population during the 1846 measles epidemic was higher in adults and in children aged <2?years. However, nowadays, children younger than 5?years and adults older than 20?years are still more likely to suffer from measles complications, despite not being fully susceptible [3]. Moreover, Strebelet al. [4] reported that the case fatality ratio is still high in children aged <1?year, lower in children aged 1?9?years, and then rises again in teenagers and adults. The reported data suggest that greater morbidity and mortality in adults is not a unique feature of first-contact measles epidemics.