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2020 ; 148
(ä): 252-257
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Mitigating the impact of COVID-19 on oncology: Clinical and operational lessons
from a prospective radiation oncology cohort tested for COVID-19
#MMPMID32474129
Ning MS
; McAleer MF
; Jeter MD
; Minsky BD
; Ghafar RA
; Robinson IJ
; Nitsch PL
; Zaebst DJ
; Todd SE
; Nguyen J
; Lin SH
; Liao Z
; Lee P
; Gunn GB
; Klopp AH
; Dabaja BS
; Nguyen QN
; Chronowski GM
; Bloom ES
; Koong AC
; Das P
Radiother Oncol
2020[Jul]; 148
(ä): 252-257
PMID32474129
show ga
BACKGROUND AND PURPOSE: The COVID-19 pandemic warrants operational initiatives to
minimize transmission, particularly among cancer patients who are thought to be
at high-risk. Within our department, a multidisciplinary tracer team
prospectively monitored all patients under investigation, tracking their test
status, treatment delays, clinical outcomes, employee exposures, and quarantines.
MATERIALS AND METHODS: Prospective cohort tested for SARS-COV-2 infection over 35
consecutive days of the early pandemic (03/19/2020-04/22/2020). RESULTS: A total
of 121 Radiation Oncology patients underwent RT-PCR testing during this
timeframe. Of the 7 (6%) confirmed-positive cases, 6 patients were admitted (4
warranting intensive care), and 2 died from acute respiratory distress syndrome.
Radiotherapy was deferred or interrupted for 40 patients awaiting testing. As the
median turnaround time for RT-PCR testing decreased from 1.5 (IQR: 1-4) to ?1-day
(P < 0.001), the median treatment delay also decreased from 3.5 (IQR: 1.75-5) to
1 business day (IQR: 1-2) [P < 0.001]. Each patient was an exposure risk to a
median of 5 employees (IQR: 3-6.5) through prolonged close contact. During this
timeframe, 39 care-team members were quarantined for a median of 3 days (IQR:
2-11), with a peak of 17 employees simultaneously quarantined. Following
implementation of a "dual PPE policy," newly quarantined employees decreased from
2.9 to 0.5 per day. CONCLUSION: The severe adverse events noted among these
confirmed-positive cases support the notion that cancer patients are vulnerable
to COVID-19. Active tracking, rapid diagnosis, and aggressive source control can
mitigate the adverse effects on treatment delays, workforce incapacitation, and
ideally outcomes.
|*Betacoronavirus
[MESH]
|COVID-19
[MESH]
|Cohort Studies
[MESH]
|Coronavirus Infections/*complications/diagnosis/prevention & control
[MESH]
|Humans
[MESH]
|Neoplasms/*complications/radiotherapy
[MESH]
|Pandemics/prevention & control
[MESH]
|Pneumonia, Viral/*complications/diagnosis/prevention & control
[MESH]