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10.1016/j.radonc.2020.05.037

http://scihub22266oqcxt.onion/10.1016/j.radonc.2020.05.037
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suck abstract from ncbi


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pmid32474129
      Radiother+Oncol 2020 ; 148 (ä): 252-257
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  • Mitigating the impact of COVID-19 on oncology: Clinical and operational lessons from a prospective radiation oncology cohort tested for COVID-19 #MMPMID32474129
  • Ning MS ; McAleer MF ; Jeter MD ; Minsky BD ; Ghafar RA ; Robinson IJ ; Nitsch PL ; Zaebst DJ ; Todd SE ; Nguyen J ; Lin SH ; Liao Z ; Lee P ; Gunn GB ; Klopp AH ; Dabaja BS ; Nguyen QN ; Chronowski GM ; Bloom ES ; Koong AC ; Das P
  • Radiother Oncol 2020[Jul]; 148 (ä): 252-257 PMID32474129 show ga
  • BACKGROUND AND PURPOSE: The COVID-19 pandemic warrants operational initiatives to minimize transmission, particularly among cancer patients who are thought to be at high-risk. Within our department, a multidisciplinary tracer team prospectively monitored all patients under investigation, tracking their test status, treatment delays, clinical outcomes, employee exposures, and quarantines. MATERIALS AND METHODS: Prospective cohort tested for SARS-COV-2 infection over 35 consecutive days of the early pandemic (03/19/2020-04/22/2020). RESULTS: A total of 121 Radiation Oncology patients underwent RT-PCR testing during this timeframe. Of the 7 (6%) confirmed-positive cases, 6 patients were admitted (4 warranting intensive care), and 2 died from acute respiratory distress syndrome. Radiotherapy was deferred or interrupted for 40 patients awaiting testing. As the median turnaround time for RT-PCR testing decreased from 1.5 (IQR: 1-4) to ?1-day (P < 0.001), the median treatment delay also decreased from 3.5 (IQR: 1.75-5) to 1 business day (IQR: 1-2) [P < 0.001]. Each patient was an exposure risk to a median of 5 employees (IQR: 3-6.5) through prolonged close contact. During this timeframe, 39 care-team members were quarantined for a median of 3 days (IQR: 2-11), with a peak of 17 employees simultaneously quarantined. Following implementation of a "dual PPE policy," newly quarantined employees decreased from 2.9 to 0.5 per day. CONCLUSION: The severe adverse events noted among these confirmed-positive cases support the notion that cancer patients are vulnerable to COVID-19. Active tracking, rapid diagnosis, and aggressive source control can mitigate the adverse effects on treatment delays, workforce incapacitation, and ideally outcomes.
  • |*Betacoronavirus [MESH]
  • |COVID-19 [MESH]
  • |Cohort Studies [MESH]
  • |Coronavirus Infections/*complications/diagnosis/prevention & control [MESH]
  • |Humans [MESH]
  • |Neoplasms/*complications/radiotherapy [MESH]
  • |Pandemics/prevention & control [MESH]
  • |Pneumonia, Viral/*complications/diagnosis/prevention & control [MESH]
  • |Prospective Studies [MESH]
  • |Radiation Oncology/methods [MESH]
  • |Real-Time Polymerase Chain Reaction [MESH]


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