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2020 ; 52
(ä): 110-115
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Changes in breast cancer management during the Corona Virus Disease 19 pandemic:
An international survey of the European Breast Cancer Research Association of
Surgical Trialists (EUBREAST)
#MMPMID32502796
Gasparri ML
; Gentilini OD
; Lueftner D
; Kuehn T
; Kaidar-Person O
; Poortmans P
Breast
2020[Aug]; 52
(ä): 110-115
PMID32502796
show ga
BACKGROUND: Corona Virus Disease 19 (COVID-19) had a worldwide negative impact on
healthcare systems, which were not used to coping with such pandemic. Adaptation
strategies prioritizing COVID-19 patients included triage of patients and
reduction or re-allocation of other services. The aim of our survey was to
provide a real time international snapshot of modifications of breast cancer
management during the COVID-19 pandemic. METHODS: A survey was developed by a
multidisciplinary group on behalf of European Breast Cancer Research Association
of Surgical Trialists and distributed via breast cancer societies. One reply per
breast unit was requested. RESULTS: In ten days, 377 breast centres from 41
countries completed the questionnaire. RT-PCR testing for SARS-CoV-2 prior to
treatment was reported by 44.8% of the institutions. The estimated time interval
between diagnosis and treatment initiation increased for about 20% of
institutions. Indications for primary systemic therapy were modified in 56%
(211/377), with upfront surgery increasing from 39.8% to 50.7% (p < 0.002) and
from 33.7% to 42.2% (p < 0.016) in T1cN0 triple-negative and
ER-negative/HER2-positive cases, respectively. Sixty-seven percent considered
that chemotherapy increases risks for developing COVID-19 complications.
Fifty-one percent of the responders reported modifications in chemotherapy
protocols. Gene-expression profile used to evaluate the need for adjuvant
chemotherapy increased in 18.8%. In luminal-A tumours, a large majority (68%)
recommended endocrine treatment to postpone surgery. Postoperative radiation
therapy was postponed in 20% of the cases. CONCLUSIONS: Breast cancer management
was considerably modified during the COVID-19 pandemic. Our data provide a base
to investigate whether these changes impact oncologic outcomes.
|Antineoplastic Agents, Hormonal/*therapeutic use
[MESH]
|Antineoplastic Agents, Immunological/*therapeutic use
[MESH]