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2020 ; 10
(13
): 5932-5942
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Optimizing use of theranostic nanoparticles as a life-saving strategy for
treating COVID-19 patients
#MMPMID32483428
Itani R
; Tobaiqy M
; Al Faraj A
Theranostics
2020[]; 10
(13
): 5932-5942
PMID32483428
show ga
On the 30(th) of January 2020, the World Health Organization fired up the sirens
against a fast spreading infectious disease caused by a newly discovered Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and gave this disease the
name COVID-19. While there is currently no specific treatment for COVID-19,
several off label drugs approved for other indications are being investigated in
clinical trials across the globe. In the last decade, theranostic nanoparticles
were reported as promising tool for efficiently and selectively deliver
therapeutic moieties (i.e. drugs, vaccines, siRNA, peptide) to target sites of
infection. In addition, they allow monitoring infectious sides and treatment
responses using noninvasive imaging modalities. While intranasal delivery was
proposed as the preferred administration route for therapeutic agents against
viral pulmonary diseases, NP-based delivery systems offer numerous benefits to
overcome challenges associated with mucosal administration, and ensure that these
agents achieve a concentration that is many times higher than expected in the
targeted sites of infection while limiting side effects on normal cells. In this
article, we have shed light on the promising role of nanoparticles as effective
carriers for therapeutics or immune modulators to help in fighting against
COVID-19.