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2020 ; 11
(1
): 207
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Intravenous infusion of human umbilical cord Wharton s jelly-derived mesenchymal
stem cells as a potential treatment for patients with COVID-19 pneumonia
#MMPMID32460839
Zhang Y
; Ding J
; Ren S
; Wang W
; Yang Y
; Li S
; Meng M
; Wu T
; Liu D
; Tian S
; Tian H
; Chen S
; Zhou C
Stem Cell Res Ther
2020[May]; 11
(1
): 207
PMID32460839
show ga
The novel coronavirus disease 2019 (COVID-19) has grown to be a global public
health emergency since patients were first detected in Wuhan, China. Thus far, no
specific drugs or vaccines are available to cure the patients with COVID-19
infection. The immune system and inflammation are proposed to play a central role
in COVID-19 pathogenesis. Mesenchymal stem cells (MSCs) have been shown to
possess a comprehensive powerful immunomodulatory function. Intravenous infusion
of MSCs has shown promising results in COVID-19 treatment. Here, we report a case
of a severe COVID-19 patient treated with human umbilical cord Wharton's
jelly-derived MSCs (hWJCs) from a healthy donor in Liaocheng People's Hospital,
China, from February 24, 2020. The pulmonary function and symptoms of the patient
with COVID-19 pneumonia was significantly improved in 2?days after hWJC
transplantation, and recovered and discharged in 7?days after treatment. After
treatment, the percentage and counts of lymphocyte subsets (CD3(+), CD4(+), and
CD8(+) T cell) were increased, and the level of IL-6, TNF-?, and C-reactive
protein is significantly decreased after hWJC treatment. Thus, the intravenous
transplantation of hWJCs was safe and effective for the treatment of patients
with COVID-19 pneumonia, especially for the patients in a critically severe
condition. This report highlights the potential of hWJC infusions as an effective
treatment for COVID-19 pneumonia.